Antibody deficiencies present with recurrent sinopulmonary infections with encapsulated bacteria. Cellular deficiencies present with atypical mycobacterial and salmonella infections; or mucocutaneous candidiasis and autoimmune endocrinopathy. Combined deficiencies present with failure to thrive, diarrhoea, opportunistic infection, and/or rash; or thrombocytopenia with bleeding and bruising, eczema, and/or recurrent infection with encapsulated organisms; or chronic sinopulmonary disease, cerebellar ataxia, oculocutaneous telangiectasia, and/or malignancy; or hypocalcaemic seizures due to hypoparathyroidism, cardiac disease, abnormal facies, and/or infection; or recurrent, serious pyogenic infections (also opportunistic infections). Phagocyte defects present with deep-seated infection and/or abscess with granuloma formation; or recurrent serious bacterial infections, delayed separation of the umbilical cord, poor wound healing, and/or lack of pus; or chronic dermatitis, recurrent serious infection of lungs with pneumatocoeles, skin infections, bone fragility, and/or failure to shed primary teeth. Complement deficiencies present with autoimmune disease and bacterial infections; or neisserial infection; or recurrent infections with encapsulated bacteria.

Tests include tests for B-cell function, cellular immune function, phagocytic cell function, and complement function.

Diagnosis of secondary hypogammaglobulinaemias is not covered.